Global Stabilization of Boolean Networks to Control the Heterogeneity of Cellular Responses.

ABSTRACT: Boolean networks (BNs) have been widely used as a useful model for molecular regulatory networks in systems biology. In the state space of BNs, attractors represent particular cell phenotypes. For targeted therapy of cancer, there is a pressing need to control the heterogeneity of cellular responses to the targeted drug by reducing the number of attractors associated with the ill phenotypes of cancer cells. Here, we present a novel control scheme for global stabilization of BNs to a unique fixed point. Using a sufficient condition of global stabilization with respect to the adjacency matrix, we can determine a set of constant controls so that the controlled BN is steered toward an unspecified fixed point which can then be further transformed to a desired attractor by subsequent control. Ou

SUBMITTER: Yang JM 

PROVIDER: S-EPMC6060448 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature