CIGene: a literature-based online resource for cancer initiation genes.

ABSTRACT:

Background

Cancer initiation genes (CIGs) are genes that can directly promote cell proliferation or induce cancer. There are thousands of published studies identifying various CIGs; however, no systematic collection or description is available.

Results

To construct a CIG reference for genetic screening, we have collected 177 human genes curated from 1507 PubMed abstracts. To facilitate data queries and browsing, the identified CIGs along with extensive bioinformatic annotations were stored in an online database called CIGene. Initial functional analysis revealed an overlooked role for cell motility in cancer initiation. Subsequent cross-referencing of known tumor suppressor genes and oncogenes against the 177 CIGs identified 96 and 81 CIGs with and without known oncogenic ro

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6060465 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature