Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common form of dementia, and it affects more women than men. Mitochondrial dysfunction (MD) plays a key role in AD, and it is detectable at an early stage of the degenerative process in peripheral tissues, such as peripheral mononuclear blood cells (PBMCs). However, whether these changes are also reflected in cerebral energy metabolism and whether sex-specific differences in mitochondrial function occur are not clear. Therefore, we estimated the correlation between mitochondrial function in PBMCs and brain energy metabolites and examined sex-specific differences in healthy participants to elucidate these issues.

Methods

The current pilot study included 9 male and 15 female healthy adults (mean age 30.8 ± 7.1 years). Respiration

SUBMITTER: Silaidos C 

PROVIDER: S-EPMC6060503 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature