Host factors determine the evolution of infection with Staphylococcus aureus to gangrenous mastitis in goats.

ABSTRACT: Staphylococcus aureus is the major cause of very severe mastitis of dairy goats. The initial objective of our study was to fine-tune an experimental model of infection of the goat mammary gland with two strains of S. aureus and two lines of goats (low and high somatic cell score lines). Following the challenge, the 10 infected goats divided in two clear-cut severity groups, independently of the S. aureus strain and the goat line. Five goats developed very severe mastitis (of which four were gangrenous) characterized by uncontrolled infection (UI group), whereas the other five kept the infection under control (CI group). The outcome of the infection was determined by 18 h post-infection (hpi), as heralded by the bacterial milk concentration at 18 hpi: more than 10⁷/mL in the UI g

SUBMITTER: Rainard P 

PROVIDER: S-EPMC6060506 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature