Serum periostin levels following small bone fractures, long bone fractures and joint replacements: an observational study.

ABSTRACT:

Background

In asthma, serum periostin may potentially be used as a biomarker in the management of patients with Type-2 eosinophilic airway inflammation. However, serum periostin may be influenced by factors other than Type 2 inflammation, potentially confounding its interpretation. We aimed to measure change in periostin following bone injury.

Methods

102 adults without asthma were recruited into three groups: joint replacement surgery, long bone fracture, short bone fracture. Participants underwent seven measurements of serum periostin over 26 weeks after bone injury, and prior to surgery in the joint replacement group. Differences in periostin were measured using a ratio of geometric mean (RGM), with comparison made with pre-surgery (joint replacement) or 26 week (long and

SUBMITTER: Varughese R 

PROVIDER: S-EPMC6060508 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature