Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer's disease.

ABSTRACT:

Background

Processing of degraded speech is a promising model for understanding communication under challenging listening conditions, core auditory deficits and residual capacity for perceptual learning and cerebral plasticity in major dementias.

Methods

We compared the processing of sine-wave-degraded speech in 26 patients with primary progressive aphasia (non-fluent, semantic, and logopenic variants), 10 patients with typical Alzheimer's disease and 17 healthy control subjects. Participants were required to identify sine-wave words that were more predictable (three-digit numbers) or less predictable (place names). The change in identification performance within each session indexed perceptual learning. Neuroanatomical associations of degraded speech processing were assesse

SUBMITTER: Hardy CJD 

PROVIDER: S-EPMC6060531 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature