Wnt evolution and function shuffling in liberal and conservative chordate genomes.

ABSTRACT:

Background

What impact gene loss has on the evolution of developmental processes, and how function shuffling has affected retained genes driving essential biological processes, remain open questions in the fields of genome evolution and EvoDevo. To investigate these problems, we have analyzed the evolution of the Wnt ligand repertoire in the chordate phylum as a case study.

Results

We conduct an exhaustive survey of Wnt genes in genomic databases, identifying 156 Wnt genes in 13 non-vertebrate chordates. This represents the most complete Wnt gene catalog of the chordate subphyla and has allowed us to resolve previous ambiguities about the orthology of many Wnt genes, including the identification of WntA for the first time in chordates. Moreover, we create the first complete

SUBMITTER: Somorjai IML 

PROVIDER: S-EPMC6060547 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature