Enhanced biosynthesis of phenazine-1-carboxamide by engineered Pseudomonas chlororaphis HT66.

ABSTRACT:

Background

Phenazine-1-carboxamide (PCN), a phenazine derivative, is strongly antagonistic to fungal phytopathogens. The high PCN biocontrol activity fascinated researcher's attention in isolating and identifying novel bacterial strains combined with engineering strategies to target PCN as a lead molecule. The chemical route for phenazines biosynthesis employs toxic chemicals and display low productivities, require harsh reaction conditions, and generate toxic by-products. Phenazine biosynthesis using some natural phenazine-producers represent remarkable advantages of non-toxicity and possibly high yield in environmentally-friendlier settings.

Results

A biocontrol bacterium with antagonistic activity towards fungal plant pathogens, designated as strain HT66, was isolated fro

SUBMITTER: Peng H 

PROVIDER: S-EPMC6060551 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature