PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells.

ABSTRACT:

Background

Regulation of vascular endothelial growth factor receptor-2 (VEGFR2) signaling is a control point that determines the extent of vascular tree formation. Recent studies demonstrated an important role played by VEGFR2 endothelial trafficking in control of its activity and suggested the involvement of a phosphotyrosine phosphatase 1b (PTP1b) in this process. This study was designed to define the role of PTP1b in endothelial VEGFR2 signaling and its role in regulation of angiogenesis and arteriogenesis.

Methods and results

We generated mice carrying an endothelial-specific deletion of PTP1b and examined the effect of this knockout on VEGF signaling, angiogenesis, and arteriogenesis in vitro and in vivo. PTP1b knockout endothelial cells had increased VEGF-dependent act

SUBMITTER: Lanahan AA 

PROVIDER: S-EPMC6060619 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature