Leveraging Experimental Details for an Improved Understanding of Host-Pathogen Interactome.

ABSTRACT: An increasing proportion of curated host-pathogen interaction (HPI) information is becoming available in interaction databases. These data represent detailed, experimentally-verified, molecular interaction data, which may be used to better understand infectious diseases. By their very nature, HPIs are context dependent, where the outcome of two proteins as interacting or not depends on the precise biological conditions studied and approaches used for identifying these interactions. The associated biology and the technical details of the experiments identifying interacting protein molecules are increasing being curated using defined curation standards but are overlooked in current HPI network modeling. Given the increase in data size and complexity, awareness of the process and variables in

SUBMITTER: Ammari M 

PROVIDER: S-EPMC6060636 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature