Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future.

ABSTRACT: Despite continued advances in neonatal medicine, sepsis remains a leading cause of death worldwide in neonatal intensive care units. The clinical presentation of sepsis in neonates varies markedly from that in older children and adults, and distinct acute inflammatory responses results in age-specific inflammatory and protective immune response to infection. This review first provides an overview of the neonatal immune system, then covers current mainstream, and experimental preventive and adjuvant therapies in neonatal sepsis. We also discuss how the distinct physiology of the perinatal period shapes early life immune responses and review strategies to reduce neonatal sepsis-related morbidity and mortality. A summary of studies that characterize immune ontogeny and neonatal sepsis is pres

SUBMITTER: Schuller SS 

PROVIDER: S-EPMC6060673 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature