Toxicity mechanism in fetal lung fibroblast cells for multi-walled carbon nanotubes defined by chemical impurities and dispersibility.

ABSTRACT: Multi-walled carbon nanotubes (MWCNTs) are beneficial in a wide range of applications in fields such as electronics, optics and nano-medicine, so knowledge concerning their effect on human health is important. Physiochemical properties of MWCNTs can greatly affect their toxicity, however, there are no reports discussing the effect of size and chemical composition of MWCNTs on the toxic response of human lung cells. In this study, MWCNTs of two different purity grades were characterized and their toxic effects were compared on normal fetal lung fibroblast MRC-5 cells. The toxic effect on MRC-5 cells following 1-3 days exposure to low concentrations of research grade (RG) and industrial grade (IG) MWCNTs were studied using multiple biological assays. MWCNTs uptake in MRC-5 cells was analyzed

SUBMITTER: Shinde A 

PROVIDER: S-EPMC6060676 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature