Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner.

ABSTRACT: Scope: Particle-induced lung injury is a kind of comprehensive pulmonary disease with not only inflammation but also fibrosis. Bixin is a natural compound that is widely used as a food additive. Our previous studies demonstrated that bixin could alleviate inflammation in ventilation-induced acute lung injury as well as UV-exposure caused skin damage. But whether it could depress silica-induced long-term comprehensive lung injury and the mechanism of bixin in this protection have not yet been studied. Methods: A murine SiO₂-induced long-term comprehensive lung injury model was established through silica intratracheal instillation. To elucidate the effects and mechanisms of bixin in silica-induced pulmonary inflammation and fibrosis, we treated mice with bixin follow

SUBMITTER: Xue L 

PROVIDER: S-EPMC6060687 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature