Cytotoxic and sublethal effects of silver nanoparticles on tendon-derived stem cells - implications for tendon engineering.

ABSTRACT: Tendon injuries occur commonly in sports and workplace. Tendon-derived stem cells (TDSCs) have great potential for tendon healing because they can differentiate into functional tenocytes. To grow TDSCs properly in vivo, a scaffold is needed. Silver nanoparticles (AgNPs) have been used in a range of biomedical applications for their anti-bacterial and -inflammatory effects. AgNPs are therefore expected to be a good scaffolding coating material for tendon engineering. Yet, their cytotoxicity in TDSCs remains unknown. Moreover, their sublethal effects were mysterious in TDSCs. In our study, decahedral AgNPs (43.5 nm in diameter) coated with polyvinylpyrrolidone (PVP) caused a decrease in TDSCs' viability beginning at 37.5 μg ml^-1 but showed non-cytotoxic effects at concentra

SUBMITTER: Cheung TS 

PROVIDER: S-EPMC6060715 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature