Smoking, disease characteristics and serum cytokine levels in patients with primary Sjogren's syndrome.

ABSTRACT: Smoking affects several disease processes. Epidemiological studies have previously found a negative association between primary Sjögren's syndrome (pSS) and smoking. The aim of this study was to examine whether markers of disease activity and cytokine expression in pSS patients differ between ever and never smokers. Fifty-one consecutive pSS patients and 33 population controls were included in the study. Clinical and standard laboratory parameters were registered. Serum cytokines (IL-1β, IL-2, IL-3, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, IL-18, IL-33, IFN-α, IFN-γ, TNF-α, EGF, BAFF, Fas-ligand, RANTES, TGF-β1) were assessed. A positive lip biopsy was less prevalent among ever smoking patients compared to never smokers (81 vs 100%; p = 0.03). However, except for TNF-α, which was higher in e

SUBMITTER: Olsson P 

PROVIDER: S-EPMC6060795 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature