Height and body fatness and colorectal cancer risk: an update of the WCRF-AICR systematic review of published prospective studies.

ABSTRACT:

Purpose

There is no published dose-response meta-analysis on the association between height and colorectal cancer risk (CRC) by sex and anatomical sub-site. We conducted a meta-analysis of prospective studies on the association between height and CRC risk with subgroup analysis and updated evidence on the association between body fatness and CRC risk.

Methods

PubMed and several other databases were searched up to November 2016. A random effects model was used to calculate dose-response summary relative risks (RR's).

Results

47 studies were included in the meta-analyses including 50,936 cases among 7,393,510 participants. The findings support the existing evidence regarding a positive association of height, general and abdominal body fatness and CRC risk. The summary R

SUBMITTER: Abar L 

PROVIDER: S-EPMC6060816 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature