Reduced anterior cingulate grey matter volume in painful hand osteoarthritis.

ABSTRACT:

Objective

Increasing evidence supports the role of central sensitisation in osteoarthritis (OA) pain. In this study, we used neuroimaging to compare pain-processing regions of the brain in participants with and without hand OA. We then assessed for volumetric changes in these brain regions following treatment with centrally acting analgesics.

Methods

Participants with hand OA (n = 28) underwent T1-weighted MRI of the brain before and after 12 weeks of treatment with pregabalin, duloxetine or placebo. Grey matter volume in the anterior cingulate cortex (ACC), insular cortex and thalamus was compared to non-OA control subjects (n = 11) using FreeSurfer regional volumetric analysis and voxel-based morphometry, and evaluated for differences pre- and post-treatment.

Results

SUBMITTER: Russell MD 

PROVIDER: S-EPMC6060828 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature