Expansion of gene clusters, circular orders, and the shortest Hamiltonian path problem.

ABSTRACT: Clusters of paralogous genes such as the famous HOX cluster of developmental transcription factors tend to evolve by stepwise duplication of its members, often involving unequal crossing over. Gene conversion and possibly other mechanisms of concerted evolution further obfuscate the phylogenetic relationships. As a consequence, it is very difficult or even impossible to disentangle the detailed history of gene duplications in gene clusters. In this contribution we show that the expansion of gene clusters by unequal crossing over as proposed by Walter Gehring leads to distinctive patterns of genetic distances, namely a subclass of circular split systems. Furthermore, when the gene cluster was left undisturbed by genome rearrangements, the shortest Hamiltonian paths with respect to genetic d

SUBMITTER: Prohaska SJ 

PROVIDER: S-EPMC6060901 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature