Ontology highlight
ABSTRACT:
SUBMITTER: Oroujeni M
PROVIDER: S-EPMC6060960 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Oroujeni Maryam M Andersson Ken G KG Steinhardt Xenia X Altai Mohamed M Orlova Anna A Mitran Bogdan B Vorobyeva Anzhelika A Garousi Javad J Tolmachev Vladimir V Löfblom John J
Amino acids 20180504 8
Epidermal growth factor receptor (EGFR) is overexpressed in a number of cancers and is the molecular target for several anti-cancer therapeutics. Radionuclide molecular imaging of EGFR expression should enable personalization of anti-cancer treatment. Affibody molecule is a promising type of high-affinity imaging probes based on a non-immunoglobulin scaffold. A series of derivatives of the anti-EGFR affibody molecule ZEGFR:2377, having peptide-based cysteine-containing chelators for conjugation ...[more]