SERMs Promote Anti-Inflammatory Signaling and Phenotype of CD14+ Cells.

ABSTRACT: Signaling via estrogen receptors (ER) is recognized as an essential part of the immune regulation, and ER-mediated signaling is involved in autoimmune reactions. Especially ERα activation in immune cells has been suggested to skew cytokine production toward Th2/M2-type mediators, which can have protective effect on inflammatory diseases and reduce Th1 and Th17 responses. These effects are caused by increased alternative activation of macrophages and changes in the activation of different T cell populations. In humans, hormonal status has been shown to have a major impact on several inflammatory diseases. Selective estrogen receptor modulators (SERMs) are ER ligands that regulate ER actions in a tissue-specific manner mostly lacking the adverse effects of steroid hormones. The impact of SER

SUBMITTER: Polari L 

PROVIDER: S-EPMC6061028 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature