Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.

ABSTRACT: Drug-target binding kinetics (as determined by association and dissociation rate constants, k_on and k_off) can be an important determinant of the kinetics of drug action. However, the effect compartment model is used most frequently instead of a target binding model to describe hysteresis. Here we investigate when the drug-target binding model should be used in lieu of the effect compartment model. The utility of the effect compartment (EC), the target binding kinetics (TB) and the combined effect compartment-target binding kinetics (EC-TB) model were tested on either plasma (EC_PL, TB_PL and EC-TB_PL) or brain extracellular fluid (ECF) (EC_ECF, TB_ECF and EC-TB_ECF) morphine concentrations and EEG amplitude i

SUBMITTER: de Witte WEA 

PROVIDER: S-EPMC6061075 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature