External validation of four dementia prediction models for use in the general community-dwelling population: a comparative analysis from the Rotterdam Study.

ABSTRACT: To systematically review the literature for dementia prediction models for use in the general population and externally validate their performance in a head-to-head comparison. We selected four prediction models for validation: CAIDE, BDSI, ANU-ADRI and DRS. From the Rotterdam Study, 6667 non-demented individuals aged 55 years and older were assessed between 1997 and 2001. Subsequently, participants were followed for dementia until 1 January, 2015. For each individual, we computed the risk of dementia using the reported scores from each prediction model. We used the C-statistic and calibration plots to assess the performance of each model to predict 10-year risk of all-cause dementia. For comparisons, we also evaluated discriminative accuracy using only the age component of these risk scor

SUBMITTER: Licher S 

PROVIDER: S-EPMC6061119 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature