Temporal association patterns and dynamics of amyloid-β and tau in Alzheimer's disease.

ABSTRACT: The elusive relationship between underlying pathology and clinical disease hampers diagnosis of Alzheimer's disease (AD) and preventative intervention development. We seek to understand the relationship between two classical AD biomarkers, amyloid-β_1-42 (Aβ_1-42) and total-tau (t-tau), and define their trajectories across disease development, as defined by disease onset at diagnosis of mild cognitive impairment (MCI). Using longitudinal data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we performed a correlation analysis of biomarkers CSF Aβ_1-42 and t-tau, and longitudinal quantile analysis. Using a mixed effects model, with MCI onset as an anchor, we develop linear trajectories to describe the rate of change across disease development. These

SUBMITTER: Ower AK 

PROVIDER: S-EPMC6061138 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature