Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Islet-specific autoantibodies can predict the development of type 1 diabetes. However, it remains unclear if B cells, per se, contribute to the causal pancreatic immunopathology. We aimed to identify phenotypic signatures of disease progression among naive and memory B cell subsets in the peripheral blood of individuals with type 1 diabetes.

Methods

A total of 69 participants were recruited across two separate cohorts, one for discovery purposes and the other for validation purposes. Each cohort comprised two groups of individuals with type 1 diabetes (one with newly diagnosed type 1 diabetes and the other with long-standing type 1 diabetes) and one group of age- and sex-matched healthy donors. The phenotypic characteristics of circulating naive and memory B

SUBMITTER: Powell WE 

PROVIDER: S-EPMC6061155 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature