Immune Abnormalities in Autism Spectrum Disorder-Could They Hold Promise for Causative Treatment?

ABSTRACT: Autism spectrum disorders (ASD) are characterized by impairments in language and communication development, social behavior, and the occurrence of stereotypic patterns of behavior and interests. Despite substantial speculation about causes of ASD, its exact etiology remains unknown. Recent studies highlight a link between immune dysfunction and behavioral traits. Various immune anomalies, including humoral and cellular immunity along with abnormalities at the molecular level, have been reported. There is evidence of altered immune function both in cerebrospinal fluid and peripheral blood. Several studies hypothesize a role for neuroinflammation in ASD and are supported by brain tissue and cerebrospinal fluid analysis, as well as evidence of microglial activation. It has been shown that imm

SUBMITTER: Gladysz D 

PROVIDER: S-EPMC6061181 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature