Mitochondrial toxicity of organic arsenicals: membrane permeability transition pore opening and respiratory dysfunction.

ABSTRACT: In order to clarify the mitochondrial toxicity mechanism of the organic arsenical MOPIMP (2-methoxy-4-(((4-(oxoarsanyl) phenyl) imino) methyl) phenol), research was carried out at the sub-cell level based on the previous finding that the compound MOPIMP can damage the mitochondria by triggering a burst of ROS. After investigating its influence on isolated mitochondria in vitro, it was demonstrated that a high dose of MOPIMP with short-term exposure can induce mitochondrial swelling, decrease the membrane potential, enhance the permeability of H⁺ and K⁺, and induce membrane lipid peroxidation, indicating that it can result in an MPT process in a ROS-mediated and Ca²⁺-independent manner. Additionally, MPT was also aggravated as a r

SUBMITTER: Fan XY 

PROVIDER: S-EPMC6061234 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature