Effects of chlorhexidine gluconate oral care on hospital mortality: a hospital-wide, observational cohort study.

ABSTRACT: PURPOSE:Chlorhexidine oral care is widely used in critically and non-critically ill hospitalized patients to maintain oral health. We investigated the effect of chlorhexidine oral care on mortality in a general hospitalized population. METHODS:In this single-center, retrospective, hospital-wide, observational cohort study we included adult hospitalized patients (2012-2014). Mortality associated with chlorhexidine oral care was assessed by logistic regression analysis. A threshold cumulative dose of 300 mg served as a dichotomic proxy for chlorhexidine exposure. We adjusted for demographics, diagnostic category, and risk of mortality expressed in four categories (minor, moderate, major, and extreme). RESULTS:The study cohort included 82,274 patients of which 11,133 (14%) received chlorhexid

SUBMITTER: Deschepper M 

PROVIDER: S-EPMC6061438 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature