Assessment of synergistic thyroid disrupting effects of a mixture of EDCs in ovariectomized rats using factorial analysis and dose addition.

ABSTRACT: Endocrine disrupting chemicals (EDCs) have been implicated in a broad spectrum of health problems related to reproduction, thyroid function, neurodevelopment, and metabolism. In many cases, EDCs in the environment are at extremely low concentrations which rarely induce health problems alone, however, a mixture of these EDCs may interact and induce potential additive and synergistic effects. Many mixture studies on EDCs were conducted in terms of high doses with the direct effect addition method, which didn't comply with the dose-response relationship of toxicants in the "S" or "U" shaped curves. In the present study, the thyroid disrupting effects of a mixture of three EDCs, propylthiouracil (PTU), polychlorinated biphenyls (PCBs), and ammonium perchlorate (AP), were measured in an ovariec

SUBMITTER: Chen H 

PROVIDER: S-EPMC6061468 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature