Impact of selected drugs and their binary mixtures on the germination of Sorghum bicolor (sorgo) seeds.

ABSTRACT: The aim of this study was to assess the toxicological potential of binary drug mixtures and individual drugs under different pH conditions with different inorganic ion additions on the germination of Sorghum bicolor (sorgo) seeds. To assess whether the given drug mixtures were more phytotoxic than the individual compounds, concentration addition (CA) and independent action (IA) approaches were applied to estimate the predicted phytotoxicity values, followed by calculations of the MDR (model deviation factor) to determine the deviation from the predicted values. Binary mixtures of chloramphenicol with ketoprofen, diclofenac sodium, and oxytetracycline hydrochloride proved to be synergistic. The pH changes had the largest impact on the phytotoxicity of the diclofenac sodium and ketoprofen so

SUBMITTER: Wieczerzak M 

PROVIDER: S-EPMC6061511 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature