Patterns and frequency of renal abnormalities in Fanconi anaemia: implications for long-term management.

ABSTRACT: BACKGROUND:Fanconi anaemia (FA) is an inherited disease with bone marrow failure, variable congenital and developmental abnormalities, and cancer predisposition. With improved survival, non-haematological manifestations of FA become increasingly important for long-term management. While renal abnormalities are recognized, detailed data on patterns and frequency and implications for long-term management are sparse. METHODS:We reviewed clinical course and imaging findings of FA patients with respect to renal complications in our centre over a 25-year period to formulate some practical suggestions for guidelines for management of renal problems associated with FA. RESULTS:Thirty patients including four sibling sets were reviewed. On imaging, 14 had evidence of anatomical abnormalities of the

SUBMITTER: Sathyanarayana V 

PROVIDER: S-EPMC6061664 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature