A systematic review of genome-wide research on psychotic experiences and negative symptom traits: new revelations and implications for psychiatry.

ABSTRACT: We present a systematic review of genome-wide research on psychotic experience and negative symptom (PENS) traits in the community. We integrate these new findings, most of which have emerged over the last four years, with more established behaviour genetic and epidemiological research. The review includes the first genome-wide association studies of PENS, including a recent meta-analysis, and the first SNP heritability estimates. Sample sizes of <10 000 participants mean that no genome-wide significant variants have yet been replicated. Importantly, however, in the most recent and well-powered studies, polygenic risk score prediction and linkage disequilibrium (LD) score regression analyses show that all types of PENS share genetic influences with diagnosed schizophrenia and that negative

SUBMITTER: Ronald A 

PROVIDER: S-EPMC6061705 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature