Mechanistic insight into ROS and neutral lipid alteration induced toxicity in the human model with fins (Danio rerio) by industrially synthesized titanium dioxide nanoparticles.

ABSTRACT: The toxicological impact of TiO₂ nanoparticles on the environment and human health has been extensively studied in the last few decades, but the mechanistic details were unknown. In this study, we evaluated the impact of industrially prepared TiO₂ nanoparticles on the biological system using zebrafish embryo as an in vivo model. The industrial synthesis of TiO₂ nanoparticles was mimicked on the lab scale using the high energy ball milling (HEBM) method by milling bulk TiO₂ particles for 5 h, 10 h, and 15 h in an ambient environment. The physiochemical properties were characterized by standard methods like field emission scanning electron microscopy (FESEM), dynamic light scattering (DLS), X-ray diffraction (XRD) and UV-Visible spectroscopy

SUBMITTER: Verma SK 

PROVIDER: S-EPMC6061716 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature