Reorganization of cortical oscillatory dynamics underlying disinhibition in frontotemporal dementia.

ABSTRACT: The distribution of pathology in frontotemporal dementia is anatomically selective, to distinct cortical regions and with differential neurodegeneration across the cortical layers. The cytoarchitecture and connectivity of cortical laminae preferentially supports frequency-specific oscillations and hierarchical information transfer between brain regions. We therefore predicted that in frontotemporal dementia, core functional deficits such as disinhibition would be associated with differences in the frequency spectrum and altered cross-frequency coupling between frontal cortical regions. We examined this hypothesis using a 'Go-NoGo' response inhibition paradigm with 18 patients with behavioural variant frontotemporal dementia and 20 healthy aged-matched controls during magnetoencephalography

SUBMITTER: Hughes LE 

PROVIDER: S-EPMC6061789 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature