Function, dynamics and evolution of network motif modules in integrated gene regulatory networks of worm and plant.

ABSTRACT: Gene regulatory networks (GRNs) consist of different molecular interactions that closely work together to establish proper gene expression in time and space. Especially in higher eukaryotes, many questions remain on how these interactions collectively coordinate gene regulation. We study high quality GRNs consisting of undirected protein-protein, genetic and homologous interactions, and directed protein-DNA, regulatory and miRNA-mRNA interactions in the worm Caenorhabditis elegans and the plant Arabidopsis thaliana. Our data-integration framework integrates interactions in composite network motifs, clusters these in biologically relevant, higher-order topological network motif modules, overlays these with gene expression profiles and discovers novel connections between modules and regulato

SUBMITTER: Defoort J 

PROVIDER: S-EPMC6061849 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature