ADPredict: ADP-ribosylation site prediction based on physicochemical and structural descriptors.

ABSTRACT:

Motivation

ADP-ribosylation is a post-translational modification (PTM) implicated in several crucial cellular processes, ranging from regulation of DNA repair and chromatin structure to cell metabolism and stress responses. To date, a complete understanding of ADP-ribosylation targets and their modification sites in different tissues and disease states is still lacking. Identification of ADP-ribosylation sites is required to discern the molecular mechanisms regulated by this modification. This motivated us to develop a computational tool for the prediction of ADP-ribosylated sites.

Results

Here, we present ADPredict, the first dedicated computational tool for the prediction of ADP-ribosylated aspartic and glutamic acids. This predictive algorithm is based on (i) physicochemi

SUBMITTER: Lo Monte M 

PROVIDER: S-EPMC6061869 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature