Effects of ambient PM_2.5 and 9-nitroanthracene on DNA damage and repair, oxidative stress and metabolic enzymes in the lungs of rats.

ABSTRACT: Ambient fine particulate matter (PM_2.5) is a complex mixture associated with lung cancer risk. PM_2.5-bound nitro-polycyclic aromatic hydrocarbons (NPAHs) have been demonstrated to possess mutagenicity and carcinogenicity. Previous studies showed that PM_2.5 induced DNA damage, whereas there is little knowledge of whether 9-nitroanthracene (9-NA), a typical compound of NPAHs in PM_2.5, causes DNA damage. Also, the regulating mechanisms of PM_2.5 and 9-NA in DNA damage and repair are not yet fully established. Here we sought to investigate the molecular mechanisms of DNA damage and repair in the lungs of male Wistar rats exposed to PM_2.5 (1.5 mg per kg body weight) or three different dosages of 9-NA. And then DNA strand breaks, 8

SUBMITTER: Li R 

PROVIDER: S-EPMC6061955 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature