Endotyping of non-allergic, allergic and mixed rhinitis patients using a broad panel of biomarkers in nasal secretions.

ABSTRACT:

Background

Endotyping chronic rhinitis has proven hardest for the subgroup of non-allergic rhinitis (NAR) patients. While IgE-related inflammation is typical for allergic rhinitis (AR), no markers have been found that can be seen to positively identify NAR. A further complication is that AR and NAR might co-exist in patients with mixed rhinitis. As previous studies have considered only a limited number of inflammatory mediators, we wanted to explore whether a wider panel of mediators could help us refine the endotyping in chronic rhinitis patients.

Objective

To endotype chronic rhinitis, and non-allergic rhinitis in particular, with help of molecular or cellular markers.

Method

In this study we included 23 NAR patients without allergen sensitizations and with persiste

SUBMITTER: Segboer CL 

PROVIDER: S-EPMC6061980 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature