Oxidative stress and inflammatory responses involved in dietary nickel chloride (NiCl₂)-induced pulmonary toxicity in broiler chickens.

ABSTRACT: The respiratory system is the primary target of nickel or nickel compound toxicity after inhalation exposure. There are no reports on the effects of nickel or nickel compounds on the lung via dietary administration at present. This study aimed to investigate pulmonary toxicity induced by dietary NiCl₂ in broiler chickens by using histopathology, qRT-PCR, and ELISA. In comparison with the control group, NiCl₂ intake induced oxidative damage to DNA (upregulation of 8-OHdG) and lipid peroxidation (upregulation of MDA), which was associated with the upregulation of NO and the downregulation of the expression levels and activities of pulmonary CuZn-SOD, Mn-SOD, CAT, GSH-Px, GR and GST mRNA. Also, the T-AOC activity, GSH content, ability to inhibit the generation of

SUBMITTER: Deng J 

PROVIDER: S-EPMC6062018 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature