A local and global sensitivity analysis of a mathematical model of coagulation and platelet deposition under flow.

ABSTRACT: The hemostatic response involves blood coagulation and platelet aggregation to stop blood loss from an injured blood vessel. The complexity of these processes make it difficult to intuit the overall hemostatic response without quantitative methods. Mathematical models aim to address this challenge but are often accompanied by numerous parameters choices and thus need to be analyzed for sensitivity to such choices. Here we use local and global sensitivity analyses to study a model of coagulation and platelet deposition under flow. To relate with clinical assays, we measured the sensitivity of three specific thrombin metrics: lag time, maximum relative rate of generation, and final concentration after 20 minutes. In addition, we varied parameters of three different classes: plasma protein le

SUBMITTER: Link KG 

PROVIDER: S-EPMC6062055 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature