Testing an optimally weighted combination of common and/or rare variants with multiple traits.

ABSTRACT: Recently, joint analysis of multiple traits has become popular because it can increase statistical power to identify genetic variants associated with complex diseases. In addition, there is increasing evidence indicating that pleiotropy is a widespread phenomenon in complex diseases. Currently, most of existing methods test the association between multiple traits and a single genetic variant. However, these methods by analyzing one variant at a time may not be ideal for rare variant association studies because of the allelic heterogeneity as well as the extreme rarity of rare variants. In this article, we developed a statistical method by testing an optimally weighted combination of variants with multiple traits (TOWmuT) to test the association between multiple traits and a weighted combin

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6062080 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature