A mathematical and computational model of the calcium dynamics in Caenorhabditis elegans ASH sensory neuron.

ABSTRACT: We propose a mathematical and computational model that captures the stimulus-generated Ca2+ transients in the C. elegans ASH sensory neuron. The rationale is to develop a tool that will enable a cross-talk between modeling and experiments, using modeling results to guide targeted experimental efforts. The model is built based on biophysical events and molecular cascades known to unfold as part of neurons' Ca2+ homeostasis mechanism, as well as on Ca2+ signaling events. The state of ion channels is described by their probability of being activated or inactivated, and the remaining molecular states are based on biochemically defined kinetic equations or known biochemical motifs. We estimate the parameters of the model using experimental data of hyperosmotic stimulus-evoked Ca2+ transients de

SUBMITTER: Mirzakhalili E 

PROVIDER: S-EPMC6062085 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature