First trimester prenatal screening biomarkers and gestational diabetes mellitus: A systematic review and meta-analysis.

ABSTRACT: Biomarkers commonly assessed in prenatal screening have been associated with a number of adverse perinatal and birth outcomes. However, it is not clear whether first trimester measurements of prenatal screening biomarkers are associated with subsequent risk of gestational diabetes mellitus (GDM). We aimed to systematically review and statistically summarize studies assessing the relationship between first trimester prenatal screening biomarker levels and GDM development. We comprehensively searched PubMed/MEDLINE, EMBASE, CINAHL, and Scopus (from inception through January 2018) and manually searched the reference lists of all relevant articles. We included original, published, observational studies examining the association of first trimester pregnancy associated plasma protein-A (PAPP-A)

SUBMITTER: Donovan BM 

PROVIDER: S-EPMC6062092 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature