Mussel-inspired PEGylated carbon nanotubes: biocompatibility evaluation and drug delivery applications.

ABSTRACT: Carbon nanotubes (CNTs) have been widely examined for biomedical applications. However, surface functionalization of CNTs with polymers is often required to improve their application performance. To obtain these CNT-based polymer nanocomposites, surface-initiated polymerization strategies are generally adopted. However, all of these methods rely on the surface oxidation of CNTs, which is a rather complex and time-consuming procedure, and involves hazardous reagents. In this work, a facile and efficient bio-inspired strategy was developed for surface PEGylation of CNTs via a combination of mussel-inspired chemistry and the Michael addition reaction. The potential biomedical applications of these PEGylated CNTs were evaluated for intracellular delivery of a normally used anticancer dr

SUBMITTER: Xu H 

PROVIDER: S-EPMC6062158 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature