Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice.

ABSTRACT: Imaging dynamics at different temporal and spatial scales is essential for understanding the biological complexity of living organisms, disease state and progression. Optoacoustic imaging has been shown to offer exclusive applicability across multiple scales with excellent optical contrast and high resolution in deep-tissue observations. Yet, efficient visualization of multi-scale dynamics remained difficult with state-of-the-art systems due to inefficient trade-offs between image acquisition time and effective field of view. Herein, we introduce the spiral volumetric optoacoustic tomography technique that provides spectrally enriched high-resolution contrast across multiple spatiotemporal scales. In vivo experiments in mice demonstrate a wide range of dynamic imaging capabilities,

SUBMITTER: Dean-Ben XL 

PROVIDER: S-EPMC6062167 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature