Alkyl chain modulated cytotoxicity and antioxidant activity of bioinspired amphiphilic selenolanes.

ABSTRACT: A series of amphiphilic conjugates of dihydroxy selenolane (DHS) and monoamine selenolane (MAS), which we had previously reported to inhibit lipid peroxidation and assist the oxidative protein folding reaction respectively in cell free systems, were evaluated for cytotoxicity, associated mechanisms and antioxidant effects in cells. Our results indicated that a fatty acid/alkyl group of variable chain lengths (C_6-14) as a lipophilic moiety of the DHS/MAS conjugates not only improved their ability to incorporate within the plasma membrane of cells but also modulated their cytotoxicity. In the concentration range of 1-50 μM, C₆ conjugates were non-toxic whereas the long chain (≥C₈) conjugates showed significant cytotoxicity. The induction of toxicity investiga

SUBMITTER: Verma P 

PROVIDER: S-EPMC6062215 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature