The binary, ternary and quaternary mixture toxicity of benzo[a]pyrene, arsenic, cadmium and lead in HepG2 cells.

ABSTRACT: Polycyclic aromatic hydrocarbons (PAHs) and heavy metal/loid(s) are common environmental pollutants. Toxicological interaction data on benzo[a]pyrene (B[a]P) and heavy metal/loid(s) are lacking. In this study, we have determined the combined toxicity of B[a]P, arsenic (As), cadmium (Cd) and lead (Pb) in HepG2 cells. The binary, ternary and quaternary mixture toxicity of B[a]P and heavy metal/loid(s) was predicted by using the combination index (CI)-isobologram method. This method is useful to predict the quantitative nature of an interaction between chemicals at different effect (inhibitory concentration) levels from 0.1 to 99% using computerised quantitation. A total of 11 mixtures including six binary mixtures, four ternary and one quaternary mixtures of B[

SUBMITTER: Muthusamy S 

PROVIDER: S-EPMC6062251 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature