Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective.

ABSTRACT: After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity. The pharmacological properties of APAP are the focus of some activity, with the role of the metabolite N-arachidonoylaminophenol (AM404) still a topic of debate. However, that the hepatotoxicity of APAP results from the production of the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI/NABQI) that can deplete glutathione, react with cellular macromolecules, and initiate cell death, is now beyond dispute. The disruption of cellular pathways that results from the production of NAPQI provides a source of potential biomarkers of the severity of the damage. Res

SUBMITTER: Athersuch TJ 

PROVIDER: S-EPMC6062253 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature