Effects of sub-chronic exposure to atmospheric PM_2.5 on fibrosis, inflammation, endoplasmic reticulum stress and apoptosis in the livers of rats.

ABSTRACT: Epidemiological studies have revealed that exposure to PM_2.5 is linked to liver cancer. However, the hepatic toxicity and relevant molecular mechanisms of PM_2.5 have not yet been fully described. Herein, we report on our investigation of the fibrosis, inflammation, endoplasmic reticulum (ER) stress and apoptosis in the livers of rats, caused by exposure to PM_2.5 during summer and winter in Taiyuan, China. Male SD rats were sub-chronically exposed to PM_2.5 (in summer: 0.2, 0.6, 1.5 mg per kg of b.w.; in winter: 0.3, 1.5, 2.7 mg per kg of b.w.) via intratracheal instillation once every 3 days for 60 days. The results showed that exposure to high dosages of PM_2.5 caused the following: (1) hepatic histopathological changes and liver

SUBMITTER: Li R 

PROVIDER: S-EPMC6062260 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature