Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing.

ABSTRACT: Localized surface plasmon resonance (LSPR) biosensing based on supported metal nanoparticles offers unparalleled possibilities for high-end miniaturization, multiplexing and high-throughput label-free molecular interaction analysis in real time when integrated within an opto-fluidic environment. However, such LSPR-sensing devices typically contain extremely large regions of dielectric materials that are open to molecular adsorption, which must be carefully blocked to avoid compromising the device readings. To address this issue, we made the support essentially invisible to the LSPR by carefully removing the dielectric material overlapping with the localized plasmonic fields through optimized wet-etching. The resulting LSPR substrate, which consists of gold nanodisks centered on narrow SiO<

SUBMITTER: Acimovic SS 

PROVIDER: S-EPMC6062313 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature