Testicular and epididymal toxicity induced by benzo(a)pyrene, alcohol, and their combination in Wistar rats.

ABSTRACT: Alcoholism and cigarette smoking are pervasive problems that have been implicated in human health. In this study, independent and combinative toxicities of alcohol and benzo(a)pyrene (BaP) were tested for reproductive toxicity in rats. Male Wistar rats were exposed to BaP (100 μg per kg body weight) on alternative days and alcohol (2 g per kg body weight per day) daily, either individually or in combination for 60 days. Exposure to BaP or alcohol significantly decreased the fertility index and reduced the number of implantations associated with elevated pre- and post-implantation losses. The relative weights of testes, epididymis, seminal vesicles, and prostate gland were significantly decreased in BaP or alcohol administered rats. Exposure to BaP or alcohol significantly decreased daily s

SUBMITTER: Reddy KP 

PROVIDER: S-EPMC6062366 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature